CXCL12/CXCR4 Blood Levels Can Help Diagnose Inflammation Linked to Parkinson’s, Study Suggests

Measuring blood levels of the signaling molecule CXCL12 and its receptor CXCR4 may help identify active inflammation in Parkinson’s disease patients, a study suggests. The study, “CXCL12 and CXCR4 in the Peripheral Blood of Patients with Parkinson’s Disease,” was published in Neuroimmunomodulation. CXCL12 is a small protein called a chemokine that triggers immune cells to the

Study Outlines Risk Factors for Levodopa-induced Dyskinesia in Newly Diagnosed PD Patients

Severe motor, functional, and gait impairment; cumulative levodopa exposure; anxiety, and sex are among the risk factors for developing levodopa-induced dyskinesia (LID) in people newly diagnosed  with Parkinson’s disease, according to results from the Parkinson’s Progression Markers Initiative (PPMI). The research, “Risk factors of levodopa-induced dyskinesia in Parkinson’s disease: results from the PPMI cohort,” was

Inhibiting USP13 Enzyme Can Help Destroy Toxic Alpha-Synuclein Clumps, Mouse Study Finds

Inhibiting an enzyme called USP13 may represent an attractive therapeutic target for Parkinson’s and other neurodegenerative diseases, preclinical data suggests. These findings also could hold important implications for a therapy currently being developed to treat Parkinson’s disease — nilotinib. The study, “Ubiquitin specific protease-13 independently regulates parkin ubiquitination and alpha-synuclein clearance in alpha-synucleinopathies,” was published in

Finding Hope for Today

Sometimes you can feel as if you’re at the end of your proverbial rope. You’re holding on as tight as you can, hoping the blisters on the palms of your hands won’t become totally unbearable and you let go. I was thinking about all that’s going on lately in the world: tsunamis, earthquakes, hurricanes, flooding,

Design, Development of BeatHealth System for Parkinson’s Gait Impairments Described in Study

Researchers have developed a system — a mobile app and two websites — based on musical stimuli to improve gait and reduce freezing episodes in Parkinson’s disease patients, according to a study describing the design process of the new approach. The project, called BeatHealth, involved patients, caregivers, and health professionals from the start to produce the most

UNS’ Investigational Vaccine UB-312 Holds Potential to Prevent Parkinson’s, Other Neurological Diseases, Data Show

An investigational vaccine being developed by United Neuroscience (UNS) presented several advantages over traditional vaccines to treat progressive disorders, such as Parkinson’s disease, according to preclinical data. The vaccine, called UB-312, was more selective to prevent toxic aggregates of alpha-synuclein in mouse models of the disease. These latest findings were discussed during the Parkinson’s UK Research Conference

Personalized Tissue Implants From Patients’ Own Cells Have Potential to Treat Parkinson’s, Study Suggests

A new, fully personalized tissue implant using a patient’s own materials and cells can regenerate any organ in the body with minimal risk of an immune response, according to researchers who are now exploring the approach as a potential way to treat Parkinson’s disease. The new technique was reported in the study, “Personalized Hydrogels for Engineering