Being Still Reveals Many Treasures

It is quiet behind our house this time of year. Not many people are using the pathway that stretches from one town to another. It is cold outside and it pierces my flesh, leaving me shivering as Ip stand and wait. In the silence, I can hear my teeth chatter. So, what compels me to stand out in

Smartphone App Can Identify Early Symptoms of Motor Disorders, Study Reports

A smartphone application using a touch-based model is able to accurately identify early signs of motor disorders, according to a new study. The app, developed for patients with Huntington’s disease, is also intended for people with Parkinson’s and other neurological disorders. The study, “A smartphone application for automated decision support in cognitive task based evaluation

Nuedexta Often Used to Treat Symptoms of Parkinson’s and Dementia Off-label, Study Finds

An oral medicine approved to treat pseudobulbar affect — involuntary outbursts of laughing or crying — in people with amyotrophic lateral sclerosis  or multiple sclerosis  is most often prescribed to treat those with Parkinson’s disease or dementia, a study based on U.S. health databases reports. The study “Assessment of Use of Combined Dextromethorphan and Quinidine in Patients With

Sirion and Denali Collaborating to Develop Gene Therapies for Neurodegenerative Diseases

Sirion Biotech and Denali Therapeutics have agreed to partner on the development of gene therapies for Parkinson’s disease and other neurodegenerative disorders. According to the license and collaboration agreement, the two companies will pursue the development of harmless, next-generation adeno-associated viral vectors (AAV) able to cross the blood-brain barrier — a semipermeable membrane that protects the brain against

Abnormal Brain Cell Type Leads to Parkinson’s-Related Neurodegeneration, Study Contends

Scientists have found that an abnormal version of brain cells called astrocytes contribute to the accumulation of alpha-synuclein protein, the main component of Parkinson’s disease hallmark Lewy bodies. Their study, “Patient-specific iPSC-derived astrocytes contribute to non-cell autonomous neurodegeneration in Parkinson’s disease,” was published in Stem Cell Reports. Parkinson’s disease is linked to degeneration of the

Genetic Variant Predetermines Risk of Cognitive Decline in Parkinson’s, Research Suggests

Researchers have found that Parkinson’s patients whose cognitive ability is intact, but who have a specific genetic variant, have significantly less gray matter in the regions of their brain that are related to dementia. The study with that finding, “Reduced gray matter volume in cognitively preserved COMT 158Val/Val Parkinson’s disease patients and its association with cognitive decline,”

Changes in Gait, Cognition May Be Early Signs of Idiopathic Parkinson’s, Research Suggests

Changes in gait and cognition precede a diagnosis of idiopathic (without known cause) Parkinson’s disease, and may occur earlier than typical non-motor symptoms, a study has found. The study, “Prediagnostic markers of idiopathic Parkinson’s disease: Gait, visuospatial ability and executive function,” was published in Gait & Posture. Motor symptoms in idiopathic Parkinson’s disease (IPD) are identified relatively late in the