Dual-Target Compounds Could Lead to Single and More Effective Therapy for Parkinson’s, Study Reports

Pharmacologic compounds that can act on two target molecules show promise as potential therapies for Parkinson’s disease, according to a study that details a new way of finding such compounds. The study, “Docking screens for dual inhibitors of disparate drug targets for Parkinson’s disease,” was published in the Journal of Medicinal Chemistry. Neurodegenerative diseases such

Marijuana and Parkinson’s: What Do We Really Know?

1.What’s in Marijuana? 2.Marijuana Research 3.Warning: Synthetic Marijuana 4.Clinical Studies 5.Side Effects 6.Guidelines for Medical Marijuana and Parkinson’s 7.Conclusion People with Parkinson’s disease (PD) and their physicians are both looking to answer whether medical marijuana can help manage Parkinson’s symptoms. Researchers have barely scratched the surface when it comes to marijuana and PD and previous

Mutation Common to Familial Parkinson’s and Tuberculosis May Lead to Ways of Treating Both Diseases

A mutation common to familial Parkinson’s was seen in a study focused on tuberculosis to prevent immune cells of the brain from working properly, allowing protein to accumulate in nerve cells — and, potentially, to this specific disease’s development. The study, “LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages,” appeared in

Alkahest Awarded Grant to Support Development of ALK4290 for Parkinson’s

The Michael J. Fox Foundation for Parkinson’s Research (MJFF) recently awarded Alkahest a grant to support the development of ALK4290 as a new therapy for Parkinson’s disease. The immune system plays an important role in the development and progression of Parkinson’s disease. New therapies targeting the recruitment of immune cells, or inhibiting brain inflammation, could

Non-Motor Symptoms Different Among Men and Women, Study Shows

Non-motor symptoms (NMS) in Parkinson’s disease are significantly more frequent and differ between men and women, a new study shows. The study, “Frequency of non-motor symptoms in Parkinson’s disease presenting to tertiary care centre in Pakistan: an observational, cross-sectional study,” was published in the journal BMJ Open. Parkinson’s NMS include anxiety, depression, dementia, psychosis, sleep impairment,

Brain Training Decreases Severity of Parkinson’s Freezing of Gait, Study Reports

Brain training reduces the severity and duration of freezing of gait and improves cognition and daytime sleepiness in Parkinson’s patients, a study shows. The study, “Cognitive training for freezing of gait in Parkinson’s disease: a randomized controlled trial,” appeared in the journal npj Parkinson’s Disease. Freezing of gait is a symptom of Parkinson’s disease and occurs when

Scientists Unraveling How Movement is Translated Into Desired Action

The findings of a Harvard University study are furthering understanding of the mechanisms involved in movement disorders and may open new therapeutic opportunities to treat Parkinson’s disease. The mouse study, “The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection,” was published in the journal Cell. The brain relies on the balanced activity of two nerve cell populations

Don’t Judge Me by the Absence of My Smile

Many people aren’t aware of how wide the range of Parkinson’s disease symptoms is. For example, looking at the motor symptoms alone, a patient can have any, or all, of the following: tremors, muscle rigidity, and difficulty walking. One symptom that is not common knowledge outside of the Parkinson’s community is facial masking, also known

Early Symptoms May Predict Future Psychosis in Parkinson’s Patients, Study Finds

Early sleep-related and autonomic symptoms — related to automatic or involuntary body functions — are associated with an increased risk of future psychotic symptoms in Parkinson’s disease patients, according to a recent study. These symptoms are also associated with a reduction of specific nerve cells in a region of the brain involved in memory, attention, and perception