Research

What Are the New Therapies in Trial for Parkinson’s Disease?

We always advise patients to ask their doctor what’s new in Parkinson’s disease (PD). Recently, three leading experts at the Parkinson’s Foundation Center Leadership Conference reviewed the field and updated all attendees on a several of the exciting therapies currently being tested by Albert Hung, MD, PhD, Massachusetts General Hospital (MGH); Irene Richard, MD, University of Rochester Medical Center; and…

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Parkinson’s Medications May Cause Premature Ejaculation, Case Report Suggests

Antiparkinsonian medications may cause premature ejaculation in men with Parkinson’s, according to a case series that followed eight patients. The study, “Acquired premature ejaculation in Parkinson’s disease and possible mechanisms,” was published in the International Journal of Impotence Research. Premature ejaculation is a common male sexual dysfunction and can be a source of significant distress in men and their partners. This…

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Smartphone App Designed to Help Early Detection of Parkinson’s Disease

European experts have developed a set of technology-based solutions for the early detection of Parkinson’s disease and improvement of patients’ quality of life. Led by Greek researchers at the Aristotle University of Thessaloniki, the four-year i-PROGNOSIS (Intelligent Parkinson eaRly detectiOn Guiding NOvel Supportive InterventionS) project is testing its first product in Greece, Germany, Portugal and the United Kingdom. Launched in 2017, the…

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2 Enzymes Seen to Degrade Clumps of Stress Granules, Raising Possibility of Using Them to Treat Parkinson’s

Understanding how two proteins, both enzymes, work to disassemble “stress granules” — clumps of molecules that form when cells are stressed by external factors — may help in developing treatments for Parkinson’s and other neurodegenerative disorders by creating enzymes that mimic their work, researchers report. The study, “Deubiquitylases USP5 and USP13 are recruited to and regulate heat-induced stress granules through…

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Immunosuppressant Use Linked to Lower Risk of Developing Parkinson’s in Early Study

People who take certain immunosuppressants — medicines that dampen the immune system’s response — appear to have a lower risk of developing Parkinson’s disease, new research shows. These findings support a role for the immune system in Parkinson’s, potentially raise the possibility of developing treatments to alter disease progression, at least in its early stages. “The idea that a person’s…

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First-degree Relatives at Higher Risk of Parkinson’s, Other Neuropsychiatric Disorders, Study Finds

First-degree relatives of Parkinson’s patients are more likely to develop the disease and are at a higher risk for other neuropsychiatric disorders, a study shows. The study, “Familial aggregation of Parkinson’s disease and coaggregation with neuropsychiatric diseases: a population-based cohort study,” was published in Clinical Epidemiology. Most Parkinson’s cases are considered to be sporadic, but several studies have suggested that the…

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Deep Brain Stimulation Device That Can Self-Tune Show Promise in Small Parkinson’s Study

A new and experimental deep brain stimulation (DBS) system uses feedback from the brain to fine-tune its signaling in response to signs of dyskinesia, potentially offering a more refined way to ease motor problems in Parkinson’s patients, a small feasibility study reports. The research, “Adaptive deep brain stimulation for Parkinson’s disease using motor cortex sensing,” was published in the Journal of Neural Engineering. Larger…

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Parkinson’s Disease Shares Brainwave Abnormalities with Other Neurological Disorders, Study Finds

An abnormal brain activity pattern could be a common link between Parkinson’s disease, neuropathic pain, tinnitus, and depression, an international research team suggests. The brainwave abnormality is similar in all these disorders but occurs in different regions of the brain. This discovery could lead to therapies that target all four conditions, the investigators said. Findings were published in the study, “Thalamocortical dysrhythmia…

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