Research

Psychosis in Parkinson’s Linked to Volume Changes in Specific Area of Brain, Study Says

Psychosis and cognitive impairment in patients with Parkinson’s disease may be linked to structural changes in the brain, namely a decrease in volume of an area that controls memory formation, a study suggests. The study, “Hippocampal subfield atrophy in patients with Parkinson’s disease and psychosis,” was published in the Journal of Neural Transmission. Psychosis, which usually manifests as visual hallucinations,…

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New Biosensor May Shed Light on Molecular Processes Involved in Parkinson’s

New sensors with increased sensitivity and specificity to detect interactions between proteins, fat molecules, and other biological elements, represent a powerful tool to investigate mechanisms linked to human diseases, such as Alzheimer’s or Parkinson’s. Those findings were highlighted in the study “Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces,” which was published in Nature Communications. The way biomolecules…

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What Are the New Therapies in Trial for Parkinson’s Disease?

We always advise patients to ask their doctor what’s new in Parkinson’s disease (PD). Recently, three leading experts at the Parkinson’s Foundation Center Leadership Conference reviewed the field and updated all attendees on a several of the exciting therapies currently being tested by Albert Hung, MD, PhD, Massachusetts General Hospital (MGH); Irene Richard, MD, University of Rochester Medical Center; and…

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Parkinson’s Medications May Cause Premature Ejaculation, Case Report Suggests

Antiparkinsonian medications may cause premature ejaculation in men with Parkinson’s, according to a case series that followed eight patients. The study, “Acquired premature ejaculation in Parkinson’s disease and possible mechanisms,” was published in the International Journal of Impotence Research. Premature ejaculation is a common male sexual dysfunction and can be a source of significant distress in men and their partners. This…

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Smartphone App Designed to Help Early Detection of Parkinson’s Disease

European experts have developed a set of technology-based solutions for the early detection of Parkinson’s disease and improvement of patients’ quality of life. Led by Greek researchers at the Aristotle University of Thessaloniki, the four-year i-PROGNOSIS (Intelligent Parkinson eaRly detectiOn Guiding NOvel Supportive InterventionS) project is testing its first product in Greece, Germany, Portugal and the United Kingdom. Launched in 2017, the…

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2 Enzymes Seen to Degrade Clumps of Stress Granules, Raising Possibility of Using Them to Treat Parkinson’s

Understanding how two proteins, both enzymes, work to disassemble “stress granules” — clumps of molecules that form when cells are stressed by external factors — may help in developing treatments for Parkinson’s and other neurodegenerative disorders by creating enzymes that mimic their work, researchers report. The study, “Deubiquitylases USP5 and USP13 are recruited to and regulate heat-induced stress granules through…

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Immunosuppressant Use Linked to Lower Risk of Developing Parkinson’s in Early Study

People who take certain immunosuppressants — medicines that dampen the immune system’s response — appear to have a lower risk of developing Parkinson’s disease, new research shows. These findings support a role for the immune system in Parkinson’s, potentially raise the possibility of developing treatments to alter disease progression, at least in its early stages. “The idea that a person’s…

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First-degree Relatives at Higher Risk of Parkinson’s, Other Neuropsychiatric Disorders, Study Finds

First-degree relatives of Parkinson’s patients are more likely to develop the disease and are at a higher risk for other neuropsychiatric disorders, a study shows. The study, “Familial aggregation of Parkinson’s disease and coaggregation with neuropsychiatric diseases: a population-based cohort study,” was published in Clinical Epidemiology. Most Parkinson’s cases are considered to be sporadic, but several studies have suggested that the…

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