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Cell Surface Molecule Seen as Player in Spread of Protein Clumps That Compose Lewy Bodies

How cell surface proteins participate in spreading, from one cell to another, misfolded proteins related to neurodegenerative diseases like Parkinson’s and Alzheimer’s, possibly aiding in the progression of these disorders, was seen in early research. The study, “Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates,” was published in The Journal…

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Painting with Parkinson’s: All About Art Therapy

Every year, the top Parkinson’s experts from around the world who treat people with Parkinson’s at a Parkinson’s Foundation-designated Center of Excellence (a department or clinic within a hospital that specializes in PD) convene to discuss the latest Parkinson’s research and treatments. This article summarizes the 2018 Center Leadership Conference presentation on art therapy led by art therapist and consultant…

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Ketamine Studied for Relief of Levodopa-associated Involuntary Movements

A Phase 1 trial will test the potential of ketamine — an analgesic medicine used for depression and pain — at reducing the uncontrollable, jerky movements that arise in Parkinson’s disease patients after long-term treatment with levopoda. Levodopa, probably the most common treatment for Parkinson’s disease, is effective at improving the stiffness and slowness of movement that characterize the disease. However, up to 40…

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Epilepsy Therapy Shows Neuroprotective Effects at Low Doses in Early Animal Study

An anticonvulsant medication called methsuximide may be a new approach for treating a neurodegenerative diseases that include Parkinson’s, because it shows a potential to be neuroprotective at low doses, early research reports. Specifically, this epilepsy treatment’s active molecule — α-methyl-α-phenylsuccinimide — eased movement difficulties, extended lifespans, and showed itself to be neuroprotective in a worm model of neurodegeneration. The study, “α-Methyl-α-phenylsuccinimide…

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What is Parkinson’s Disease? This is Parkinson’s Disease

My knees are shaking and it’s not from nervousness. This is Parkinson’s disease. Stiff muscles abound throughout my aching body. This is Parkinson’s disease. My lips quiver, my teeth click, smiles turn into frowns. This is Parkinson’s disease. My toes and fingers bend involuntarily because … this is Parkinson’s disease. My legs, my arms, my sides, my back, my stomach,…

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Parkinson’s Gene Therapy Now in Phase 2 Trial, VY-AADC, Continues to Show Motor Benefits, Voyager Says

Voyager Therapeutics announced likely plans to request approval of VY-AADC as a Parkinson’s gene therapy, based on feedback it received from the U.S. Food and Drug Administration (FDA) and eventual outcomes of a newly opened Phase 2 trial. The company also reported that its Phase 1 trial of VY-AADC showed improvements in patients’ motor function and reduced use of medications, among other benefits, further supporting a…

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Neuraly Raises $36M to Advance Potential Parkinson’s Therapy into Clinical Testing

Neuraly announced it has raised $36 million to advance its lead candidate NLY01 into clinical testing as a potential disease-modifying agent for Parkinson’s disease, and to develop other investigative compounds for this and similar neurodegenerative disorders. The company, a Johns Hopkins University startup, expects to start a clinical trial of NLY01 this year. “Currently, there aren’t any treatments that reverse, stop,…

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Ni un huracán nos puede parar: La Parkinson’s Foundation presenta su primera conferencia en español en Puerto Rico

Click Here For English Claudia Martínez, MD, la coordinadora de alcance hispano del Muhammad Ali Parkinson Center en Phoenix, AZ, parte del grupo de Centros de Excelencia de Parkinson’s Foundation, no se detuvo a pensar en aceptar la propuesta de ser parte del comité logístico de la primera conferencia de la fundación en el Caribe. Ella sabía lo importante que sería…

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Parkinson’s Foundation Hosts First Parkinson’s Symposium in Puerto Rico

Claudia Martinez, MD, Hispanic Outreach Coordinator at the Muhammad Ali Parkinson Center in Phoenix, AZ, a Parkinson’s Foundation Center of Excellence, did not hesitate when she was asked to join the planning committee for the first Parkinson’s Foundation conference held in the Caribbean. She knew how important this conference would be for the community and what a massive impact it…

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New Chemical Probe May Shed Light on Role of Potential Biomarker in Parkinson’s, Study Suggests

A new chemical probe that binds to a protein called DJ-1 — a sensor of oxidative stress and a potential biomarker of Parkinson’s disease — may help researchers understand how the protein participates in disease progression, a study suggests. The study, “A chemical probe to monitor the parkinsonism- associated protein DJ-1 in live cells,” was published in the ACS Chemical Biology journal.…

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