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The Simple Helps Are Big Helps

Some people’s reactions to a person with a disability can be disheartening. They stare, make thoughtless comments, point fingers, or whisper. Some people don’t know how to handle a person who has an obvious disease, disability, or illness. They may be uncomfortable around one who is disabled, which can make the disabled feel uncomfortable. A report by ABC News last August shared…

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PKG-Watch Helps in Managing Parkinson’s Symptoms and Lowering Patient Costs, Global Kinetics Reports

Global Kinetics recently announced that the use of its wearable device, Personal KinetiGraph ­­(PKG)-Watch, significantly improves the assessment and management of Parkinson’s disease symptoms, while reducing patients’ costs. These results were presented in four scientific posters at the International Congress of Parkinson’s Disease and Movement Disorders, held Oct. 5-9 in Hong Kong. The PKG-Watch is a wrist-worn device that collects data on…

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Researchers Find Pathway Responsible for Nerve Cell Death in Parkinson’s Disease

Johns Hopkins researchers have identified a specific cell death pathway named Parthanatos — after Thanatos, the ancient Greek personification of death — that leads to the physical and intellectual degeneration associated with Parkinson’s disease. They also found that a protein called PARP-1 is a key mediator of cell death via Parthanatos, supporting the potential therapeutic benefits of PARP inhibitors for halting Parkinson’s progression. “Nailing…

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Inflammation-related Protein Complex a Potential Therapy Target for Parkinson’s, Study Says

Oral administration of a small molecule specifically blocked the activation of a stress-sensing protein complex called the NLRP3 inflammasome and prevented the loss of brain cells, resulting in significantly improved motor function in a mouse model of Parkinson’s disease, a study reports. Findings also revealed that the inflammasome is activated in Parkinson’s patients. “We have used this discovery to develop improved drug candidates and…

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15 CSF Proteins Seen as Possible Biomarkers of Early Parkinson’s Fail at That Task, Study Reports

Proteins in the cerebrospinal fluid that were seen as possible diagnostic biomarkers of Parkinson’s disease cannot serve in this role, because they lack robustness and reproducibility in earlier stages of the disease, a study has found. The study, “Evaluation of cerebrospinal fluid proteins as potential biomarkers for early stage Parkinson’s disease diagnosis,” was published in PLOS One. Parkinson’s is a chronic and…

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Realizing the potential of gene therapy for neurological disorders

Promising findings from preclinical animal studies show the potential of gene therapy for treating incurable neurological disorders. Scientists have successfully used gene therapy to slow the progression and improve symptoms of disorders such as amyotrophic lateral sclerosis and Parkinson’s disease. from Parkinson’s News — ScienceDaily https://ift.tt/2SMiCUN

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We Can Handle the Truth

There’s a saying in the Parkinson’s community that I struggle with: “You don’t die from Parkinson’s.”  I understand that well-meaning people with good intentions make this statement. However, just as a natural disaster may not directly kill its victims, many deaths happen as consequences of an earthquake or hurricane. It’s the same with Parkinson’s disease.   When I was diagnosed…

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Appendix Removal Early in Life Reduces Risk of Developing Parkinson’s, Study Shows

The healthy human appendix contains Parkinson’s disease-related alpha-synuclein aggregates, and removing the organ early in a person’s life reduces the risk of developing the disease, a study has found. The study, “The vermiform appendix impacts the risk of developing Parkinson’s disease,” was published in Science Translational Medicine. The work was led by researchers at the Center for Neurodegenerative Science at…

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Parkinson’s Patients Without Cognitive Impairment Have Normal Life Expectancy, Study Suggests

While patients with some types of parkinsonism have a shorter lifespan, those with Parkinson’s disease without cognitive impairment have a normal life expectancy, a Swedish population-based study suggests. The study, “Early predictors of mortality in parkinsonism and Parkinson disease: A population-based study,” was published in the journal Neurology. Studies have shown that life expectancy for Parkinson’s patients is reduced. However, conflicting data exists…

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