Perillyl Alcohol Lowers Toxicity, Cell Death in Parkinson’s Cell Model, Study Reports

A plant-derived compound called perillyl alcohol restored cell survival and lowered oxidative stress and DNA damage in a cell model of Parkinson’s disease, according to researchers. The new study, “Evaluation of phytomedicinal potential of perillyl alcohol in an in vitro Parkinson’s Disease model,“ was published in the journal Drug Development Research. For cells to create energy, they

IL-4 Cytokine, an Anti-Inflammatory Molecule, Linked to Neuron Damage in Early Parkinson’s Study

The anti-inflammatory molecule interleukin (IL)-4 contributes to the neurodegeneration observed in Parkinson’s disease, a study in rats reports. The research, “Interleukin-4 Contributes to Degeneration of Dopamine Neurons in the Lipopolysaccharide-treated Substantia Nigra in vivo,” was published in the journal Experimental Neurobiology. Parkinson’s is characterized by the progressive loss of dopamine-producing neurons in the substantia nigra — a midbrain

IL-4 Cytokine, an Anti-Inflammatory Molecule, Linked to Neuron Damage in Early Parkinson’s Study

The anti-inflammatory molecule interleukin (IL)-4 contributes to the neurodegeneration observed in Parkinson’s disease, a study in rats reports. The research, “Interleukin-4 Contributes to Degeneration of Dopamine Neurons in the Lipopolysaccharide-treated Substantia Nigra in vivo,” was published in the journal Experimental Neurobiology. Parkinson’s is characterized by the progressive loss of dopamine-producing neurons in the substantia nigra — a midbrain

Certain MicroRNAs Could Help Diagnose Parkinson’s, Study Suggests

Specific microRNAs that are contained in tiny, cell-derived vesicles called exosomes may be biomarkers of Parkinson’s disease, according to a study. The study, “Circulating exosomal miRNAs as diagnostic biomarkers in Parkinson’s disease,” was published in the journal European Review for Medical and Pharmacological Sciences. MicroRNAs (miRNAs) are tiny bits of RNA that bind to messenger RNA

Parkinson’s Monkey Model May Help Scientists Explore Non-Motor Symptoms, Study Reports

A well-known monkey model for Parkinson’s disease — used mainly for its ability to mimic human motor symptoms — can also reflect the disease’s non-motor symptoms, including sleep disturbances, changes in the body’s natural clock, and cognitive impairment, a study shows. These results highlight the usefulness of this model to explore other, lesser known aspects

Engineered Protein May Lead to New Parkinson’s Therapy, Preclinical Study Suggests

A modified form of a protein called Nurr1 that is able to protect against nerve cell death and restore dopamine production in a preclinical setting may pave the way for a possible new Parkinson’s therapy, a study reports. The study, “Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced

Parkinson’s Subtypes Share Early Psychiatric Features, But Diverge as Disease Progresses, Study Suggests

In the early stages, three motor subtypes of Parkinson’s disease share similar psychiatric and cognitive features, with the distinct psychiatric profiles associated with each type only appearing as the disease progresses, a study suggests. The study, “Psychiatric profile of motor subtypes of de novo drug-naïve Parkinson’s disease patients,” was published in the journal Brain and Behavior. Parkinson’s disease is